J Periodontol. 2015 Mar 5:1-16. [Epub ahead of print]
Background: Many studies have been conducted to explore the association between interleukin-1β (IL-1β) C-511T polymorphism and risk of chronic periodontitis (CP), but with different or even contradictory results. We performed an updated meta-analysis to further explore their association. Methods: PubMed, CNKI (Chinese National Knowledge Infrastructure), and EMBASE were searched up to September 30, 2014 for relevant case-control studies. Two authors independently selected studies and extracted data from included studies. The meta-analysis was carried out using the Comprehensive Meta-Analysis software. Results: Nineteen case-control studies involving 2173 CP patients and 3900 healthy controls were included. Using a random-effects meta-analysis model, a non-significant association between IL-1β C-511T polymorphism and CP was identified [T vs. C: odds ratio (OR) = 1.03, 95% confidence interval (CI) = 0.85-1.25; TT vs. CC: OR = 1.03, 95% CI = 0.72-1.46; CT vs. CC: OR = 1.05, 95% CI = 0.81-1.38; (CT+TT) vs. CC: OR = 1.00, 95% CI = 0.74-1.34; TT vs. (CT + CC): OR = 0.97, 95% CI = 0.69-1.37, respectively], sensitivity analysis indicated that our results were robust. Subgroups analyses also revealed a non - significant association. No publication bias was detected. Conclusions: Based on currently available evidence, IL-1β C-511T polymorphism is not associated with the risk of developing CP. Further researchis warranted to further explore and confirm the association of genetic polymorphism and CP.
PMID：25741583 [PubMed - in process]
作者团队：曾宪涛, 邝心颖, 冷卫东, 等.