武汉大学中南医院循证与医学转化中心

科学研究

Meta-analysis on the association between toothbrushing and head and neck cancer

发布于2015-04-11 07:24:17    人阅读

Summary

Background

Epidemiological studies have focused on the association between toothbrushing and head and neck cancer (HNC). However, the question of whether toothbrushing is associated with decreased risk of HNC remains unanswered. Since there is currently no systematic review or meta-analysis available to provide quantitative findings on this important clinical question; we consequently performed this meta-analysis to investigate the association between toothbrushing and HNC risk.

Methods

We searched PubMed and Embase up to January 13 (updated on October 20), 2014 to identify observational studies that investigated the association between toothbrushing and HNC. After study section and data extraction, the meta-analysis was conducted using RevMan 5.2 software.

Results

A total of 18 case-control studies involving 7068 cases and 9990 controls were included. The meta-analysis showed that compared with highest toothbrushing frequency, lowest level was significantly increased risk of HNC 2.08 times (odds ratio = 2.08, 95% confidence interval = 1.65–2.62). This significant association remained consistent after adjusting for smoking status and alcohol consumption. No publication bias was detected.

Conclusions

This meta-analysis found frequency of toothbrushing was significantly associated with HNC risk. Effective toothbrushing may be potentially important for the prevention of HNC and we suggest that the frequency be twice per day (morning and night).

PMID:25753558 [PubMed - in process]

作者团队:曾宪涛, 冷卫东, 张超, 等.

PUBMED网址链接:http://www.ncbi.nlm.nih.gov/pubmed/25753558

首页 > 科学研究 > 发表论文 > 正文

Meta-analysis on the association between toothbrushing and head and neck cancer

发布于2015-04-11 07:24:17    人阅读

Summary

Background

Epidemiological studies have focused on the association between toothbrushing and head and neck cancer (HNC). However, the question of whether toothbrushing is associated with decreased risk of HNC remains unanswered. Since there is currently no systematic review or meta-analysis available to provide quantitative findings on this important clinical question; we consequently performed this meta-analysis to investigate the association between toothbrushing and HNC risk.

Methods

We searched PubMed and Embase up to January 13 (updated on October 20), 2014 to identify observational studies that investigated the association between toothbrushing and HNC. After study section and data extraction, the meta-analysis was conducted using RevMan 5.2 software.

Results

A total of 18 case-control studies involving 7068 cases and 9990 controls were included. The meta-analysis showed that compared with highest toothbrushing frequency, lowest level was significantly increased risk of HNC 2.08 times (odds ratio = 2.08, 95% confidence interval = 1.65–2.62). This significant association remained consistent after adjusting for smoking status and alcohol consumption. No publication bias was detected.

Conclusions

This meta-analysis found frequency of toothbrushing was significantly associated with HNC risk. Effective toothbrushing may be potentially important for the prevention of HNC and we suggest that the frequency be twice per day (morning and night).

PMID:25753558 [PubMed - in process]

作者团队:曾宪涛, 冷卫东, 张超, 等.

PUBMED网址链接:http://www.ncbi.nlm.nih.gov/pubmed/25753558

版权所有:武汉大学中南医院循证与转化医学中心
技术支持:西安渔夫网络科技有限公司
联系我们

湖北省武汉市武昌区,东湖路169号    邮编:430071

电话/传真:+86 027 67812817    邮箱:zhongnan@163.com    微博:http://weibo.com/whuznyy